Leflunomide Tablets IP 20 mg

Leflunomide Tablets IP 20 mg is a prescription medication that is primarily used for the treatment of rheumatoid arthritis and psoriatic arthritis. This drug is classified as a disease-modifying antirheumatic drug (DMARD) that helps reduce joint damage and improve physical function over time. Leflunomide is very helpful in treating autoimmune diseases in which the immune system attacks its own tissues.

Uses of Leflunomide Tablets IP 20 mg:

• Rheumatoid Arthritis: Decreases inflammation and slows the progression of the disease.
• Psoriatic Arthritis: Used to relieve joint pain, swelling, and skin symptoms.
• Off-Label Use (under physician supervision): Possible use for other autoimmune diseases such as systemic lupus erythematosus or sarcoidosis.

Mechanism of Action

Leflunomide works by inhibiting an enzyme known as dihydroorotate dehydrogenase, which is essential in the use of pyrimidines needed in DNA replication in activated lymphocytes. Inhibiting this enzyme decreases immune cell activation mediated by inflammation and joint destruction, thus controlling autoimmune responses.

How to Use Leflunomide Tablets:

Dosage:

• The standard starting dose is 100 mg a day for a loading dose of 3 days, followed by 20 mg once a day for maintenance.
• The loading dose could be omitted based on the individual’s condition or physician recommendation.

Administration:

•  Take the tablet orally with or without food.
•  Swallow the tablet whole with a glass of water.
•  Take the medication at the same time each day to maintain a constant amount of drug in your system.

Duration:

The duration for seeing the effects of leflunomide can take 4 to 6 weeks or longer. However, it is imperative to remain compliant with your doctor’s recommendation to take it regularly as scheduled!

Frequent Side Effects

• Gastrointestinal: Nausea, diarrhea, abdominal pain
• General: Headache, dizziness, fatigue
• Dermatologic: Thinning hair, rash
• Hepatic: Elevated liver enzymes; liver function tests are recommended
• Pulmonary: Cough and shortness of breath can occur very rarely.

Leflunomide Safety Tips

Regular Monitoring: Monitoring of liver function, blood pressure and white blood cell count should be performed regularly via blood tests.

Avoid Alcohol: Alcohol consumption increases the risk of liver damage.

Pregnancy Warning: Do not take Leflunomide during pregnancy or during the process of conception. Leflunomide carries the risk of major birth defects. Women of childbearing age must be on effective contraception.

Drug Elimination Protocol: If and when a pregnancy is contemplated, or serious side effects occur, a cholestyramine washout may be prescribed to rapidly remove Leflunomide.

Drug Interactions: Make sure to tell the doctor about any supplements or other medications being taken as well, especially methotrexate, NSAIDs, and live vaccines.