Sacubitril and Valsartan tablets are used to treat heart failure. This innovative medication brings together two distinct mechanisms of action to effectively manage heart failure with reduced ejection fraction (HFrEF), offering patients a new ray of hope for improved cardiac health.
Sacubitril is a neprilysin inhibitor that works by blocking an enzyme responsible for breaking down beneficial peptides in the heart. By inhibiting neprilysin, Sacubitril increases the levels of these peptides, which have vasodilatory, diuretic, and natriuretic effects. This leads to the relaxation and dilation of blood vessels, reducing the workload on the heart and improving overall cardiac function. Sacubitril contributes to symptomatic relief and helps enhance the patient’s quality of life
Valsartan is an angiotensin receptor blocker (ARB) that acts on the renin-angiotensin-aldosterone system (RAAS). By blocking the action of angiotensin II on blood vessels and adrenal glands, Valsartan promotes vasodilation and reduces blood pressure. Additionally, it helps prevent the adverse remodelling of the heart muscles that often occurs in heart failure. Valsartan’s ability to modulate the RAAS system plays a crucial role in managing the progression of heart failure.
Enhanced Cardiac Function: The combination improves heart function by promoting vasodilation and reducing fluid retention.
Reduced Mortality and Hospitalizations: Clinical trials show a significant decrease in cardiovascular mortality and heart failure-related hospitalizations.
Symptomatic Relief: Patients experience relief from symptoms like shortness of breath and fatigue, leading to improved daily comfort.
Slowed Disease Progression: Adverse cardiac remodelling is slowed, preserving heart function and potentially delaying interventions.
Simplified Regimen: Combining two mechanisms of action in one tablet streamlines treatment and enhances adherence.
Improved Quality of Life: Symptom relief and better cardiac health contribute to an enhanced overall quality of life.
Recognised Efficacy: Approved by authorities and endorsed in clinical guidelines, indicating proven efficacy and safety.
Sacubitril / Valsartan Tablets