Zioglim-M3

Metformin Hydrochloride (PR) and Glimepiride Tablets IP(500 mg + 3mg)

Zioglim M 3mg/500mg Tablet is a medicine that comes under a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes. This medicine is specifically for those patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a long-lasting issue that impacts the way our body processes glucose. People with type 2 diabetes either do not generate enough insulin, or the insulin generated is not able to process its function in the body (insulin resistance).

Zioglim M3 Tablet is a made up of two anti-diabetic drugs, namely: Glimepiride and Metformin. Glimepiride works by reviving beta cells in the pancreas that generate insulin. Thus, insulin assists in removing sugar from the blood. Metformin works by minimizing the sugar generation by cells in the liver and slows sugar absorption from the intestines. Also, it escalates the sensitivity of muscle cells to insulin, which allows these cells to exrtact sugar more effectively from the blood.

Therapeutic Indication

Zioglim M3 (Glimepiride 3 mg + Metformin Hydrochloride Prolonged Release 500 mg) is used to provide support to diet and exercise to help improve glucose regulation in adults with Type 2 Diabetes Mellitus in case where glucose levels are not well managed through dietary changes and monotherapy alone. It is intended for patients who need combination therapy to get better blood sugar management.

Mechanism of Action

Zioglim M3 combines two complementary antidiabetic agents which work to control blood sugar with different methods like:

Glimepiride 3 mg

• It falls under the category of sulfonylurea antidiabetics.
• It acts on the beta-cells of the pancreas to facilitate insulin secretion.
• It is effective at reducing fasting and postprandial blood sugar.

Metformin Hydrochloride PR 500 mg 

• Reduces hepatic glucose production
• Decreases intestinal absorption of glucose.
• Improves insulin sensitivity in peripheral tissues which allows for better glucose usage by muscles and other tissues.
• This is a prolonged-release formulation which helps to maintain a sustained glucose control. This may improve gastroitestinal tolerability.

Dosage and Administration 

• Take Zioglim M3 exactly as prescribed by your healthcare professional.
• Take the tablet with meals to reduce gastrointestinal side effects and lower the risk of hypoglycemia
• Swallow the tablet whole with water. Do not crush, chew or break the prolonged release tablet unless and until it is advised by a healthcare professional.
• It is recommended to have regular monitoring of blood glucose levels during your treatment

Benefits of Glimepiride 3mg + Metformin HCL PR 500mg Tablet

Zioglim M3 has a major benefit in the treatment of Type 2 diabetes mellitus.

Zioglim M 3mg/500mg Tablet falls under the category of anti-diabetic drugs which consists of Glimepiride and Metformin. Glimepiride helps by increasing the production of insulin in the pancreas.  Metformin helps by reducing the generation of sugar by cells in the liver and also helps in reducing the intestinal absorption.

Key Features 

• This is a dual action therapy for better control of blood glucose
• Also helps to reduce fasting and post meal blood sugar level
• It also improves insulin sensitivity
• Prolonged-release metformin offers sustained glucose-lowering action.
• This is a convenient once daily or physician directed dosing regimen
• This supports a long term diabetes management when it is used with diet and exercise

Side Effects of Zioglim M3

• Stomach pain
• Nausea
• Diarrhoea
• Vomiting
• Headache
• Metallic taste
• Hypoglycemia

Contraindications 

Zioglim M3 should not be used in patients with:

• Type 1 Diabetes Mellitus.
• Diabetic ketoacidosis.
• Severe renal impairment.
• Known hypersensitivity to glimepiride, metformin, sulfonylureas or any component of the formulation.
• Acute or chronic metabolic acidosis.

Precautions for Glimepiride 3mg + Metformin HCL PR 500mg Tablet

• It is not safe to drink alcohol with Zioglim M 3mg/500mg Tablet.
• Zioglim M 3mg/500mg Tablet should not be consumed during pregnancy as it may be dangerous.
• Zioglim M 3mg/500mg Tablet is not safe to use while breastfeeding as it may pass the toxicity to the baby through milk.
• You might not be able to drive if your blood sugar is too low or too high. It is advised not to drive if these symptoms occur.
• Zioglim M 3mg/500mg Tablet should be given with caution to patients with kidney and liver disease. Dose adjustment of Zioglim M 3mg/500mg Tablet may be needed. Please reach out to your doctor.

Storage Information 

• Store below 25°C in a cool and dry place.
• Protect from moisture and direct sunlight.
• Keep out of reach of children.

Frequently Asked Questions (FAQ)

Can Zioglim M3 be taken with food?

Yes, you can take the tablet with meals as that helps to reduce gastrointestinal side effects. This may also decrease the risk of hypoglycemia.

Can I stop taking Zioglim M3 when my blood sugar becomes normal? 

No, you can continue treatment only as it is advised by your healthcare professional.

What should I do if I miss a dose? 

Remember to take the missed dose as soon as you remember. But skip it if it’s almost time for the next dose and do not take a double dose.

Can alcohol be consumed while taking Zioglim M3? 

Avoid alcohol consumption as this may increase the risk of hypoglycemia and metformin-associated lactic acidosis.