Zioglim-MV 1

Glimepiride, Voglibose & Metformin Hydrochloride (SR) Tablets – The combination of Glimepiride, Metformin, and Voglibose is utilized in adults for the management of type 2 diabetes mellitus when dietary measures, exercise, and individual therapies with two medications are inadequate to sufficiently regulate blood sugar levels. It serves as a combination of medications aimed at treating type 2 diabetes mellitus in adults. It aids in controlling blood sugar levels in individuals diagnosed with diabetes.

Composition

Glimepiride 1mg + Metformin HCL SR 500mg + Voglibose 0.2mg Tablet

Benefits of Glimepiride, Voglibose & Metformin Hydrochloride (SR) Tablets

This is a medication that assists in controlling elevated blood glucose levels. It aids in slowing the conversion of food in our intestines to simple sugar, thereby reducing the surge in blood glucose levels following meals. It also facilitates the elimination of excess glucose from your body through urine. Reducing blood glucose levels is a crucial aspect of diabetes management.

Glimepiride, Voglibose & Metformin Hydrochloride (SR) Tablets will decrease the likelihood of mortality from cardiovascular disease for those with type 2 diabetes who already have cardiovascular disease. Regular use of this medication, alongside a balanced diet and exercise, will assist you in leading a normal, healthy lifestyle.

How Do the Glimepiride, Voglibose & Metformin Hydrochloride (SR) Tablets Works?

The mechanism through which glimepiride lowers blood glucose seems to rely on stimulating the release of insulin from functioning pancreatic beta cells and enhancing the sensitivity of peripheral tissues to insulin. Metformin enhances glucose tolerance in patients with type-2 diabetes (NIDDM), resulting in a reduction of both basal and postprandial plasma glucose. Metformin diminishes hepatic glucose production, decreases the intestinal absorption of glucose, and enhances insulin sensitivity by promoting peripheral glucose uptake and usage.

Side Effects of Glimepiride, Voglibose & Metformin Hydrochloride (SR) Tablets

• Hypoglycemia
• Change in taste
• Nausea
• Diarrhea
• Abdominal pain
• Flatulence
• Headache
• respiratory illness

Indication and Administration of Medicine

• The combination is recommended for the treatment of type 2 diabetes when diet and exercise alone fail to deliver sufficient glycemic control.
• The dosage may differ, and it should be established by a healthcare professional based on the patient’s specific requirements and treatment response.

Contraindications

Glimepiride, Voglibose & Metformin Hydrochloride (SR) Tablets should not be used by patients who have:

• Type 1 diabetes mellitus or diabetic ketoacidosis
• Severe renal dysfunction or renal insufficiency
• Metabolic acidosis (including lactic acidosis)
• An allergy to any ingredient in the preparation (glimepiride, metformin, or voglibose)

Expert Advice for Glimepiride, Voglibose & Metformin Hydrochloride (SR) Tablets

• Take it with meals to reduce the likelihood of an upset stomach.
• It can lead to hypoglycemia when combined with other antidiabetic medications, alcohol, or if meals are delayed or missed. Carry a source of sugar with you for instant relief.
• Your doctor may frequently monitor your liver function. Notify your doctor if you experience symptoms such as abdominal pain, loss of appetite, or jaundice.
• Check your feet routinely for any indications of blisters, sores, or cuts. Individuals with diabetes need to pay extra attention to their feet.
• Refrain from consuming alcohol as it may influence blood sugar levels and interfere with your medications.
• Meditation and deep breathing techniques are both useful methods for reducing stress.
• Take tablets precisely as prescribed by your physician. Adhere to the indicated dosage and schedule. Avoid altering the dosage or stopping the medication without consulting your doctor.

Warnings & Precautions

• Caution advised in elderly people and people with renal or hepatic dysfunction
• Possibility of lactic acidosis (though infrequent) due to metformin, particularly in dehydrated state, infections, or renal dysfunction
• Likely to produce hypoglycemia, especially when used concurrently with insulin, sulfonylureas, alcohol, or fasting
• Monitoring of blood sugar, glycosylated hemoglobin, renal function tests, and liver function tests advisable
• Temporary withdrawal necessary prior to iodinated contrast imaging studies

Pregnancy and Lactation Use

• It is to be used in pregnancy only upon the prescription of a physician
• Insulin is more suitable in cases where better glycaemic control is required during pregnancy
• May appear in the breast milk; should not be taken without the advice of a physician

Missed Dose

• If you miss a dose, take it as soon as you remember
• If it is nearly time for your next dose, skip the missed dose
• Do not take a double dose

Overdose

An overdose can result in:

• Hypoglycemia (excessive sweating, dizziness, mental confusion, loss of consciousness)
• Lactic acidosis (a rare but potentially dangerous condition characterized by fast breathing, abdominal pain, and lethargy)

Storage Instructions

• Store in a cool, dry place below 25°C
• Protect from moisture and direct sunlight
• Keep out of reach of children

FAQs

What is Glimepiride, Voglibose & Metformin SR indicated for?

It is indicated for the treatment of type 2 diabetes mellitus in adults where diet and physical activity along with monotherapy or combined oral therapy are inadequate in controlling hyperglycemia.

How does Glimepiride, Voglibose & Metformin tablet act?

The medication acts through triple pathways such that glimepiride stimulates the release of insulin from beta cells, metformin decreases gluconeogenesis by the liver, and voglibose inhibits carbohydrate hydrolysis in the gut.

Should this tablet be taken empty stomach?

No, it is recommended to take this medication along with food in order to minimize gastric side effects as well as the action of voglibose.

What are the common side effects of this diabetes medicine?

Frequent side effects include nausea, diarrhea, abdominal pain, flatulence, headaches, and hypoglycemia in particular.

Is this combination medication safe for chronic treatment of diabetes?

Yes, provided that it is used under the guidance of physician who would monitor regularly your blood glucose, renal, and hepatic function.